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In this work, firefly luciferase activities are studied to create a new model for the kinetics of the system. In the previous studies, the experimental and simulation results of light intensities generated from a firefly luciferin-luciferase system have not been identical. We show that small changes in the previous theoretical model allow a far better match to experimental results. In addition to...
This study evaluates parameter estimation methodology in the context of neuronal signaling networks. Based on the results of a previous study, four parameter estimation methods, Evolutionary Programming, Genetic Algorithm, Multistart, and Levenberg-Marquardt, are selected. All the reaction rate constants of the test case, the protein kinase C (PKC) pathway model, are estimated using the selected four...
Despite the transient phenomenon of activation of G-pro-tein by primary messengers on the plasma membrane, the protein kinase C (PKC) gets activated via the amplified signaling cascade stimulated by G-protein. The second messengers activating PKC play a vital role in this cascade. Therefore it is important to mimic their behavior in the model, where the activation of the G-protein initiates the liberation...
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