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Desmin is an intermediate filament protein that can be ADP-ribosylated by arginine-specific mono(ADP-ribosyl) transferase. Stoichiometric modification of desmin by the transferase causes inhibition of assembly of desmin into 10-nm intermediate filaments (Huanget al.,1993,Biochem. Biophys. Res. Commun.197, 570–577). In this work, the sites of modification that can affect disassembly have been identified...
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