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Key points
Cl− and HCO3− had similar paracellular permeabilities in human airway epithelia.
PCl/PNa of airway epithelia was unaltered by pH 7.4 vs. pH 6.0 solutions.
Under basal conditions, calculated paracellular HCO3− flux was secretory.
Cytokines that increased airway surface liquid pH decreased or reversed paracellular HCO3− flux.
HCO3− flux through the paracellular pathway may counterbalance...
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