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Roles for transforming growth factor-α (TGFα) in the stomach include cell migration and proliferation, inhibition of acid secretion, and cytoprotection. The authors have previously shown increased TGFα expression in rat gastric mucosa in response to acute gastric injury. They also have shown that TGFα immunoreactivity is increased in the gastric mucosa of four patients with Menetrier's disease. To...
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