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Cytokinesis is the final stage of cell division and produces two independent daughter cells. Vesicles derived from internal membrane stores, such as the Golgi, lysosomes, and early and recycling endosomes accumulate at the intracellular bridge (ICB) during cytokinesis. Here, we use electron tomography to show that many ICB vesicles are not independent but connected, forming a newly described ICB vesicular...
We have shown previously thatRab6, a small, trans‐Golgi‐localizedGTPase, acts upstream of the conserved oligomericGolgi complex (COG) andZW10/RINT1 retrograde tether complexes to maintainGolgi homeostasis. In this article, we present evidence from the unbiased and high‐resolution approach of electron microscopy and electron tomography thatRab6 is essential to the trans‐Golgi trafficking of two morphological classes of coated vesicles; the larger corresponds to clathrin‐coated vesicles and the smaller to coat protein...
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