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Bone marrow specimens from 185 patients with plasma cell disorders (PCD) were investigated by fluorescence in situ hybridization (FISH) in order to determine the temporal sequence of cytogenetic aberrations. In 25 cases combined FISH analysis has also been performed at single cell level. Clonal evolution was observed in 16% of cases. The Δ13 was preceded by t(4;14)(p16;q32) and t(14;16)(q32;q23) translocations...
A 12‐year‐old male with pre‐B‐cell acute lymphoblastic leukemia with cryptic BCR/ABL rearrangement underwent sex‐mismatched allogeneic bone marrow transplantation (allo‐BMT). Contradictory results were provided by various chimerism analyses 3 months later. Y‐chromosome‐specific quantitative polymerase chain reaction and sex chromosome‐specific interphase fluorescence in situ hybridization (i‐FISH)...
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