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Sodium beraprost, a newly synthesized PGl2 analogue inhibited in a dose-dependent manner formyl-methionyl-leucyl-phenylalanine (fMLP) induced superoxide generation of human neutrophils, but it had no effect on the superoxide synthesis by phorbol myristate acetate (PMA) or A23187. Sodium beraprost inhibited Ca 2+ influx in fMLP stimulated neutrophils employing fluorometry and confocal...
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