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Rationale Angiogenesis plays an important role in wound healing and tumor growth. Fucosyltransferases synthesize fucosylated glycans and may play a major role in vascular biology. Objective To examine the role of an alpha(1,2) fucosyltransferase (Fut2) in angiogenesis. Methods and results We found that Fut2 mRNA and protein expression is inducible in human dermal microvascular endothelial cells...
Systemic sclerosis (scleroderma [SSc]) is a multifactorial disease characterized by inflammation, extensive and progressive fibrosis, and multiple vasculopathies. The vascular manifestations can be seen early in the pathogenesis of the disease and include malformed capillaries, Raynaud’s phenomenon, and digital ulcers. As the disease progresses, the vasculopathy proceeds to significant clinical manifestations,...
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