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Biallelic polymorphisms in the promoter region of the TNF-α gene (TNFA) and in the first intron of the TNF-β gene (TNFB) have been associated with variation in TNF-α production and with susceptibility to severe diseases. Among other functions, TNF-α plays a pivotal role in regulatory aspects of granuloma formation and sustenance. In sarcoidosis, a systemic granulomatous disorder of unknown aetiology,...
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