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Polybia-MPI (MPI), a short cationic α-helical antimicrobial peptide, exhibited excellent anticancer activity and selectivity in vitro in our previous studies. To improve its in vivo application, we synthesized an analog (MPI-1) of MPI by replacing the C terminal amide –[CO–NH 2 ] with thioamide –ψ[CS–NH 2 ]. Although there is just one atom difference, the MPI-1 exhibited some surprising...
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