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Cold-inducible RNA-binding protein (CIRP) is an RNA-binding protein that is expressed in normal testis and down-regulated after heat stress. Recent studies suggest that CIRP contributes to male fertility problems but the mechanisms are unclear. The purpose of this study was to identify the likely mechanism of CIRP in reproduction. Based on the RNA-Binding Protein Immunoprecipitation-Microarray (Chip)...
Recent studies have demonstrated that FoxO1 modulates the expression of SREBP-1c, but the exact mechanism remains unknown. Our results demonstrate that FoxO1 suppresses the SREBP-1c promoter transcriptional activity in HepG2 cells. This repression was independent of FoxO1 binding to the SREBP-1c promoter, but LXR responsive elements (LXREs) were crucial to this phenomenon. Moreover, FoxO1 also strongly...
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