Search results for: Chandana A. Reddy

Items from 1 to 20 out of 124 results

article

Primary fit tracheoesophageal puncture in primary versus salvage laryngectomy: Short‐term and long‐term complications and functional outcomes

Emese C. Kanyo, Shannon S. Wu, Chandana A. Reddy, Natalie L. Silver, more

Background Primary fit tracheoesophageal puncture (TEP) is widely preferred for individuals who have not undergone prior radiation. However, there is no consensus on the relative utility of primary‐fit TEP in the setting of salvage laryngectomy. Methods A retrospective, single‐center review was conducted of individuals undergoing laryngectomy with primary fit TEP between 2012 and 2018. Multivariable...

article

Evaluating the impact of the degree of extranodal extension on outcomes in locally advanced oral cavity cancer

Anirudh Yalamanchali, Christopher Griffith, Chandana A. Reddy, Shlomo A. Koyfman, more

Head & Neck > 46 > 9 > 2340 - 2347

Background Evaluate whether extranodal extension (ENE) extent impacts outcomes in patients with oral cavity squamous cell carcinoma (OCSCC). Methods From an institutional database, patients with OCSCC and pathologic ENE who received adjuvant treatment were included. Surgical slides were reviewed to confirm ENE extent. Multivariable Cox regression was used to relate patient/treatment characteristics...

article

Rates of osteoradionecrosis in resected oral cavity cancer reconstructed with free tissue transfer in the intensity‐modulated radiotherapy era

Shannon S. Wu, Hanna Hong, Michael Fritz, Jamie Ku, more

Head & Neck > 45 > 4 > 890 - 899

Background Resected oral cavity carcinoma defects are often reconstructed with osteocutaneous or soft‐tissue free flaps, but risk of osteoradionecrosis (ORN) is unknown. Methods This retrospective study included oral cavity carcinoma treated with free‐tissue reconstruction and postoperative IMRT between 2000 and 2019. Risk‐regression assessed risk factors for grade ≥2 ORN. Results One hundred...

article

Nasopharyngeal cancer: Incidence and prognosis of human papillomavirus and Epstein–Barr virus association at a single North American institution

Shannon S. Wu, Bonnie Chen, Christopher W. Fleming, Akeesha A. Shah, more

Head & Neck > 44 > 4 > 851 - 861

Background The prognostication of Epstein–Barr virus (EBV) and human papillomavirus (HPV) status in nasopharyngeal cancer (NPC) is unclear. Methods This retrospective study analyzed NPC from 2000 to 2019. Results Seventy‐eight patients were included: 43 EBV⁺, 12 HPV⁺, 23 EBV⁻/HPV⁻, and 0 EBV⁺/HPV⁺. All p16⁺ tumors were also positive for HPV‐CISH. Baseline characteristics were not different between...

article

Risk of thromboembolism in patients with ALK‐ and EGFR‐mutant lung cancer: A cohort study

Joanna Roopkumar, Shyam K. Poudel, Lorenzo Gervaso, Chandana A. Reddy, more

Journal of Thrombosis and Haemostasis > 19 > 3 > 822 - 829

Introduction Thromboembolism (TE) is common in patients with non‐small cell lung cancer (NSCLC) and is associated with worse outcomes. Recent advances in the understanding of NSCLC have led to the identification of molecular subtypes such as anaplastic lymphocyte kinase (ALK) and epidermal growth factor receptor (EGFR) mutations. The association of these subtypes with risk of TE has not been fully...

article

Clinical Versus Pathologic Laryngeal Cancer Staging and the Impact of Stage Change on Outcomes

Kevin J. Contrera, Bryan B. Hair, Brandon Prendes, Chandana A. Reddy, more

The Laryngoscope > 131 > 3 > 559 - 565

Objectives/Hypothesis Evaluate the impact and accuracy of clinical laryngeal cancer staging. Study Design Retrospective cohort study. Methods Two hundred sixty‐five consecutive patients with laryngeal squamous cell carcinoma who underwent total laryngectomy from 2001 to 2017 were studied. Clinical versus pathologic tumor (T) and nodal (N) categories were compared. Logistic regression and Cox...

article

Impact of active smoking on outcomes in HPV+ oropharyngeal cancer

Roy Xiao, Yvonne Pham, Matthew C. Ward, Narcissa Houston, more

Head & Neck > 42 > 2 > 269 - 280

Background The role of smoking among patients with human papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is unclear. Methods A retrospective cohort study of patients with HPV(+) OPSCC from 2001 to 2015 at a tertiary‐care institution was conducted. The primary outcome was overall survival (OS). Results Among 484 included patients, 94 (19.4%) were active smokers, 226...

article

Long‐term complications and reconstruction failures in previously radiated breast cancer patients receiving salvage mastectomy with autologous reconstruction or tissue expander/implant‐based reconstruction

Bindu V. Manyam, Chirag Shah, Neil M. Woody, Chandana A. Reddy, more

The Breast Journal > 25 > 6 > 1071 - 1078

Salvage mastectomy (SM) is the standard of care for patients with local recurrence (LR) after breast conservation therapy (BCT), often with immediate reconstruction. Complications of reconstruction are a concern for these patients, and long‐term data are limited. We sought to compare rates of complications requiring re‐operation (CRR) and reconstruction failure (RF) between autologous reconstruction...

article

Second primary tumors in patients with a head and neck paraganglioma

Kevin J. Contrera, Valeda Yong, Chandana A. Reddy, Eren Berber, more

Head & Neck > 41 > 9 > 3356 - 3361

Background There are conflicting recommendations and possibly overuse of imaging for surveillance of second primary tumors for patients with a history of head and neck paraganglioma. Methods Retrospective cohort study of 234 adults with head and neck paragangliomas (1990‐2010) followed for a mean of 7.5 ± 8.4 years. Results The rate of second paraganglioma was 1.7% after 5 years and 5.1% after...

article

Dosimetric differences between local failure and local controlled non‐small cell lung cancer patients treated with stereotactic body radiotherapy: A matched‐pair study

Tingliang Zhuang, Neil M Woody, Han Liu, Sheen Cherian, more

Journal of Medical Imaging and Radiation Oncology > 62 > 3 > 420 - 424

Introduction Concerns were raised about the accuracy of pencil beam (PB) calculation and potential underdosing of medically inoperable non‐small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT). From our institutional series, we designed a matched‐pair study where each local failure and controlled patient was matched based upon several clinical factors, to investigate...

article

A matched comparison of human papillomavirus–induced squamous cancer of unknown primary with early oropharynx cancer

Richard Blake Ross, Shlomo A. Koyfman, Chandana A. Reddy, Narcissa Houston, more

The Laryngoscope > 128 > 6 > 1379 - 1385

Objectives/Hypothesis Patients with human papillomavirus (HPV)–induced cancer of unknown primary (CUP) are generally excluded from clinical trials, despite surgical series reporting detection rates of occult oropharynx primaries of >80%. We performed a matched‐pair analysis to compare outcomes between T0N1‐3M0 HPV+ CUP and T1‐2N1‐3M0 HPV+ oropharynx known primary (OPX). Study Design Retrospective...

article

A Multi-institutional Comparison of SBRT and IMRT for Definitive Reirradiation of Recurrent or Second Primary Head and Neck Cancer

John A. Vargo, Matthew C. Ward, Jimmy J. Caudell, Nadeem Riaz, more

International Journal of Radiation Oncology*Biology*Physics > 2018 > 100 > 3 > 595-605

Two modern methods of reirradiation, intensity modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), are established for patients with recurrent or second primary squamous cell carcinoma of the head and neck (rSCCHN). We performed a retrospective multi-institutional analysis to compare methods.Data from patients with unresectable rSCCHN previously irradiated to ≥40 Gy...

article

Volume, Dose, and Fractionation Considerations for IMRT-based Reirradiation in Head and Neck Cancer: A Multi-institution Analysis

Jimmy J. Caudell, Matthew C. Ward, Nadeem Riaz, Sara J. Zakem, more

International Journal of Radiation Oncology*Biology*Physics > 2018 > 100 > 3 > 606-617

Limited data exist to guide the treatment technique for reirradiation of recurrent or second primary squamous carcinoma of the head and neck. We performed a multi-institution retrospective cohort study to investigate the effect of the elective treatment volume, dose, and fractionation on outcomes and toxicity.Patients with recurrent or second primary squamous carcinoma originating in a previously...

article

Refining Patient Selection for Reirradiation of Head and Neck Squamous Carcinoma in the IMRT Era: A Multi-institution Cohort Study by the MIRI Collaborative

Matthew C. Ward, Nadeem Riaz, Jimmy J. Caudell, Neal E. Dunlap, more

International Journal of Radiation Oncology*Biology*Physics > 2018 > 100 > 3 > 586-594

The therapeutic ratio of reirradiation for recurrent or second primary (RSP) squamous carcinoma of the head and neck may be improved in the intensity modulated radiation therapy (IMRT) era. However, patient selection for reirradiation remains challenging. We performed a multi-institution cohort study to investigate modern outcomes after IMRT-based reirradiation and to identify prognostic subgroups...

article

Tumor Control and Toxicity for Common Stereotactic Body Radiation Therapy Dose-Fractionation Regimens in Stage I Non-Small Cell Lung Cancer

Kevin L. Stephans, Neil M. Woody, Chandana A. Reddy, Matthew Varley, more

International Journal of Radiation Oncology*Biology*Physics > 2018 > 100 > 2 > 462-469

To examine the impact of stereotactic body radiation therapy (SBRT) dose on outcomes in early-stage non-small cell lung cancer in a large single-institution series.We reviewed 600 patients treated from 2003 to 2012 for early-stage non-small cell lung cancer. The SBRT dose was at physician discretion on the basis of tumor size and location. Peripheral tumors were treated to 60 Gy in 3 fractions (homogeneous...

article

Recursive partitioning analysis is predictive of overall survival for patients undergoing spine stereotactic radiosurgery

Ehsan H. Balagamwala, Jacob A. Miller, Chandana A. Reddy, Lilyana Angelov, more

Journal of Neuro-Oncology > 2018 > 137 > 2 > 289-293

Spine stereotactic radiosurgery (SRS) offers excellent radiographic and pain control for patients with spine metastases. We created a prognostic index using recursive partitioning analysis (RPA) to allow better patient selection for spine SRS. Patients who underwent single-fraction spine SRS for spine metastases were included. Primary histologies were divided into favorable (breast/prostate), radioresistant...

article

Validation of the Disease-Specific GPA for Patients With 1 to 3 Synchronous Brain Metastases in Newly Diagnosed NSCLC

Neil M. Woody, Matthew D. Greer, Chandana A. Reddy, Gregory M.M. Videtic, more

Clinical Lung Cancer > 2018 > 19 > 1 > e141-e147

The disease-specific graded prognostic assessment (DS-GPA) for brain metastases is a powerful prognostic tool but has not been validated for patients with synchronous brain metastases (SBM) in newly diagnosed non–small-cell lung cancer (NSCLC).We identified patients with newly diagnosed NSCLC with 1 to 3 SBM treated with stereotactic radiosurgery (SRS) between 1997 and 2012. We included patients whose...

article

Secondary Urethral Malignancies Following Prostate Brachytherapy

Shree Agrawal, John M. Lacy, Herman Bagga, Kenneth W. Angermeier, more

Urology > 2017 > 110 > C > 172-176

To understand urethral secondary malignancies among patients treated with brachytherapy (BRT) for primary prostate cancer.Institutional retrospective review identified 13 patients evaluated from 2003 to 2014 with urethral cancer and history of BRT monotherapy for prostate cancer. All patients were biochemically free of their primary disease and radiation-associated secondary malignancies (RASMs) were...

article

Never too old: A single-institution experience of stereotactic body radiation therapy for patients 90 years and older with early stage lung cancer

Gregory M.M. Videtic, Neil M. Woody, Chandana A. Reddy, Kevin L. Stephans

Practical Radiation Oncology > 2017 > 7 > 6 > e543-e549

To report on the patient, tumor, and treatment characteristics of patients aged 90 years or older who were treated with lung stereotactic body radiation therapy (SBRT) for early stage lung cancer and the resulting clinical outcomes.We surveyed our institutional review board–approved prospective lung SBRT data registry for patients aged 90 years or older who were treated for early stage lung cancer...

article

Intensity modulated radiation therapy with pulsed reduced dose rate as a reirradiation strategy for recurrent central nervous system tumors: An institutional series and literature review

Erin S. Murphy, Kevin Rogacki, Andrew Godley, Peng Qi, more

Practical Radiation Oncology > 2017 > 7 > 6 > e391-e399

Pulsed reduced dose rate (PRDR) is a reirradiation technique that potentially overcomes volume and dose limitations in the setting of previous radiation therapy for recurrent central nervous system (CNS) tumors. Intensity modulated radiation therapy (IMRT) has not yet been reported as a PRDR delivery technique. We reviewed our IMRT PRDR outcomes and toxicity and reviewed the literature of available...

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INFONA - science communication portal

Search results for: Chandana A. Reddy

Primary fit tracheoesophageal puncture in primary versus salvage laryngectomy: Short‐term and long‐term complications and functional outcomes

Evaluating the impact of the degree of extranodal extension on outcomes in locally advanced oral cavity cancer

Rates of osteoradionecrosis in resected oral cavity cancer reconstructed with free tissue transfer in the intensity‐modulated radiotherapy era

Nasopharyngeal cancer: Incidence and prognosis of human papillomavirus and Epstein–Barr virus association at a single North American institution

Risk of thromboembolism in patients with ALK‐ and EGFR‐mutant lung cancer: A cohort study

Clinical Versus Pathologic Laryngeal Cancer Staging and the Impact of Stage Change on Outcomes

Impact of active smoking on outcomes in HPV+ oropharyngeal cancer

Long‐term complications and reconstruction failures in previously radiated breast cancer patients receiving salvage mastectomy with autologous reconstruction or tissue expander/implant‐based reconstruction

Second primary tumors in patients with a head and neck paraganglioma

Dosimetric differences between local failure and local controlled non‐small cell lung cancer patients treated with stereotactic body radiotherapy: A matched‐pair study

A matched comparison of human papillomavirus–induced squamous cancer of unknown primary with early oropharynx cancer

A Multi-institutional Comparison of SBRT and IMRT for Definitive Reirradiation of Recurrent or Second Primary Head and Neck Cancer

Volume, Dose, and Fractionation Considerations for IMRT-based Reirradiation in Head and Neck Cancer: A Multi-institution Analysis

Refining Patient Selection for Reirradiation of Head and Neck Squamous Carcinoma in the IMRT Era: A Multi-institution Cohort Study by the MIRI Collaborative

Tumor Control and Toxicity for Common Stereotactic Body Radiation Therapy Dose-Fractionation Regimens in Stage I Non-Small Cell Lung Cancer

Recursive partitioning analysis is predictive of overall survival for patients undergoing spine stereotactic radiosurgery

Validation of the Disease-Specific GPA for Patients With 1 to 3 Synchronous Brain Metastases in Newly Diagnosed NSCLC

Secondary Urethral Malignancies Following Prostate Brachytherapy

Never too old: A single-institution experience of stereotactic body radiation therapy for patients 90 years and older with early stage lung cancer

Intensity modulated radiation therapy with pulsed reduced dose rate as a reirradiation strategy for recurrent central nervous system tumors: An institutional series and literature review

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