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A previous report indicated that the flavonoid‐rich extract of bergamot juice (BJe) exerts an anti‐inflammatory effect through the activation of SIRT1 in leukemic monocytes THP‐1 exposed to lipopolysaccharide (LPS). In this study, we deeply investigate the mode of action of BJe, along with its major flavonoids on SIRT1 through cell‐free, in silico, and invitro experimental models. In the cell‐free...
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