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To estimate the clinical value of estrogen receptor (ER) β expression in breast cancer we used an immunohistochemical method to detect the wild-type ERβ in 88 primary breast cancers. We used a highly specific polyclonal antibody to the carboxyl terminus of wild-type ERβ. This antibody reacted with neither other variant forms of ERβ nor any part of ERα. Slides were evaluated on a scale representing...
To investigate the alterations of genetic instabilities in carcinogenesis of the breast, we analyzed the allelotypic profile of 65 ductal carcinomas in situ (DCIS), compared with that of 207 invasive ductal carcinomas (IDC) of the breast. These studies were performed by means of examining microsatellite-length polymorphisms at seven loci (AluVpa, ESR, D11S988, D13S267, D16S398, D17S1159, and D17S855)...
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