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In this paper, the interactions of pepsin with CYD (cytidine) or nucleoside analogs, including FNC (2′-deoxy-2′-β-fluoro-4′-azidocytidine) and CMP (cytidine monophosphate), were investigated by fluorescence, UV–visible absorption and synchronous fluorescence spectroscopy under mimic physiological conditions. The results indicated that FNC (CYD/CMP) caused the fluorescence quenching by the formation...
The fat mass and obesity associated protein (FTO) is a potential target for anti-obesity medicines. In this paper, we have synthesized two potential inhibitors for FTO, three-member-ring compound (W3) and four-member-ring compound (W4). The interactions of fat mass and obesity-associated (FTO) protein with W3 (or W4) have been studied by spectral method. Results show the intrinsic fluorescence...
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