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Objective To evaluate the potential pharmacokinetic interactions of the anticancer agent gefitinib (Iressa®) and the oriental medications Guipi Decoction (归脾汤, GPD, Guibi-tang in Korean) and Bawu Decoction (八物汤, BWD, Palmul-tang in Korean). Methods Methylcellulose (MC, control), GPD (1,200 mg/kg), or BWD (6,000 mg/kg) was orally administered to rats either as a single dose or multiple doses prior...
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