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Stimulation of α2A‐adrenoceptors (ARs) in the prefrontal cortex (PFC) produces a beneficial effect on cognitive functions such as working memory. A previous study in our laboratory showed that α2A‐AR stimulation suppresses excitatory synaptic transmission in layer V‐VI pyramidal cells of the rat medial PFC (mPFC). However, the intracellular mechanism underlying the α2A‐AR suppression remains unclear...
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