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The medulla contains central chemosensitive cells important for the maintenance of blood gas and pH homeostasis. To identify the intrinsic chemosensitive cells, we measured responses of intracellular Ca 2+ ([Ca 2+ ] i ) and H + ([H + ] i ), and membrane potential of rat primary-cultured medullary cells to 6-s exposure to acidosis.The cells showed transient...
Ca 2+ sparks are localized intracellular Ca 2+ release events from the sarcoplasmic reticulum in muscle cells that result from synchronized opening of ryanodine receptors (RyR). In mammalian skeletal muscle, RyR1 is the predominant isoform present in adult skeletal fibers, while some RyR3 is expressed during development. Functional studies have revealed a differential role for RyR1...
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