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We have previously demonstrated the protective action of hydrogen sulfide (H2S) in 1-Methy-4-Phenylpyridinium Ion (MPP+)-induced neurotoxicity. However, the exact mechanisms of this protection remain largely unknown. Aldehyde stress and endoplasmic reticulum (ER) stress play significant roles in the neurotoxicity of MPP+. Brain derived neurotrophic factor (BDNF) is an important endogenous neuroprotectant...
Aldehyde stress contributes to molecular mechanisms of cell death and the pathogenesis of Parkinson’s disease (PD). The neurotoxin 1-Methy-4-Phenylpyridinium Ion (MPP+) is commonly used to model PD. Aldehyde dehydrogenase 2 (ALDH2) is an important enzyme detoxifying aldehydes. The aim of this study is to evaluate whether MPP+-induced neurotoxicity is involved in aldehyde stress by modulation of ALDH...
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