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Background: The bone substitute NanoBone® consists of nanocrystalline hydroxyapatite embedded in a highly porous matrix of silica gel. It promotes the healing of bone defects and is degraded by osteoclasts during bone remodeling. The present study investigates the interactions of NanoBone® with bone tissue. Methods: Granules of NanoBone® were implanted in defects of critical size in the mandible...
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