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Multilamellar liposomes of dimyristoylphosphatidylcholine, containing 4 mol% egg phosphatidic acid show at the phase transition temperature an increased permeability for non-electrolytes of M r values up to 900. This indicates that the packing defects occurring at the liquid crystalline/gel state phase boundary have a similar pore diameter (15-18 A) as the packing defects present in glycophorin-dioleoylphos-phatidylcholine...
Glycophorin incorporation into large unilamellar dioleoylphosphatidylcholine vesicles results in a greatly increased bilayer permeability for non-electrolytes of M r -values up to 900. This suggests that glycophorin aggregates induce the formation of pores with a 15-18 Å diameter.
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