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Serotonin and histamine are components of human and rodent mast cell secretory granules.Serotonin and histamine are stored in the same compartment as serglycin proteoglycan. Here we addressed the possibility that serglycin may be involved in their storage and/or release.The storage and release of histamine and serotonin was studied in bone marrow–derived mast cells (BMMCs) and in peritoneal mast cells...
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