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The ability to modify cellular properties such as adhesion is of interest in the design and performance of biotechnology-related processes. The current study was undertaken in order to evaluate the effectiveness of modulating cellular adhesion in HeLa cells from a genomics perspective. Using DNA microarrays, differences in gene expression between two phenotypically distinct, anchorage-dependent and...
High density growth of Escherichia coli especially in large bioreactors may temporarily expose the cells to oxygen limitation as a result of a local inadequate oxygen supply or intermittently high concentrations of cells and nutrients. Although short, these periods can potentially alter bacterial metabolism, affecting both growth and recombinant proteins production capability, and thus lowering process...
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