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Magnesium sulfate has been recognized as a neuroprotective agent against hypoxia–ischemia, mainly by the protection from the excitotoxicity associated with increased glutamate concentration. However, the mechanism of MgSO 4 action is not fully understood and is considerably controversial.During the 2 first hours of life, the asphyxiated full-term newborns were treated intravenously with one...
Objectives: Perinatal asphyxia represents a major cause of acute brain impairment and mortality in neonates. To develop the effective therapies able to reduce post-asphyxial damages, the understanding of biochemical processes accompanying asphyxia appears to be of the great relevance.Design and methods: The activities of protein kinases A and C, and tyrosine kinases in erythrocyte membranes of healthy...
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