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Prion protein (PrP) protects neural cells against oxidative stress, hypoxia, ischemia, and hypoglycemia. In the present study we confirm that cultured PrP‐deficient neurons are more sensitive to oxidative stress than wild‐type neurons and present the novel findings that wild‐type, but not PrP‐deficient astrocytes protect wild‐type cerebellar neurons against oxidative stress and that exosomes released...
Clusterin, a protein associated with multiple functions, is expressed in a wide variety of mammalian tissues. Although clusterin is known to be involved in neurodegenerative diseases, ageing, and tumorigenesis, a detailed analysis of the consequences of gain- or loss-of-function approaches has yet to be performed to understand the underlying mechanisms of clusterin functions. Since clusterin levels...
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