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Programmed cell death‐1 (PD‐1) and its ligands, PD‐L1 and PD‐L2 maintain self‐tolerance and modulate physiological immune responses. Recently, targeting the PD‐1/PD‐L1 pathway with blocking antibodies has emerged as a potentially promising approach to treat advanced cancers in adult patients. Since tumor PD‐L1 expression is currently considered the most important predictive biomarker for successful...
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