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NFATs and FOXP3 are linked with impaired regulatory T‐cells (Tregs) in generalized vitiligo (GV). To elucidate calcium mediated NFATc1 signalling pathway and its effect on Treg suppressive capacity in GV. Calcium levels, calcineurin, NFATc1 and GSK‐3β activity and cell proliferation were assessed in 52 GV patients and 50 controls by calcium assay kit, calcineurin phosphatase assay kit, TransAM NFATc1...
Regulatory T cells (Tregs) are involved in the suppression of activated T cells in generalized vitiligo (GV).
The study was aimed to investigate Tregs functional defects in Treg:CD8+ and Treg:CD4+ T cells' co‐culture systems of 55 GV patients and 45 controls. CD8+ and CD4+ T‐cell proliferation was assessed by BrdU assay; production of IL‐10, TGF‐β and IFN‐γ cytokines was assessed by ELISA; and FOXP3,...
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