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The ATP-binding cassette transporter A1 encoded by ABCA1 plays an integral role in the efflux of cellular cholesterol and phospholipids, but may also be a central mediator of β-amyloid (Aβ) processing. Here, genetic association of the common R219K variant of ABCA1 is shown with cerebrospinal fluid (CSF) Aβ1–42 levels, reinforcing emerging evidence of a connection between lipid and Aβ metabolism. In...
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