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The chloride channel (ClC) protein family comprises both chloride (Cl−) channels and chloride/proton (Cl−/H+) antiporters. In prokaryotes and eukaryotes, these proteins mediate the movement of Cl− ions across the membrane. In eukaryotes, ClC proteins play a role in the stabilization of membrane potential, epithelial ion transport, hippocampal neuroprotection, cardiac pacemaker activity and vesicular...
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