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Because macrophages are involved in the pathology of many diseases, targeting delivery of therapeutic molecules to macrophages is important issue. Polyrotaxanes (PRXs) composed of multiple cyclodextrins threaded with a linear polymer were utilized as a therapeutic agent for metabolic disease and for regulating cellular metabolism. For targeting delivery of PRXs to macrophages, carboxyethyl ether group‐modified...
Front Cover: Carboxylated polyrotaxanes interact with scavenger receptor class A and selectively uptake into macrophages. Additionally, the supramolecular structure of the polyrotaxanes significantly affects uptake efficiency in macrophages. This study would provide important insights in the therapeutic applications of polyrotaxanes. This is reported by Hideto Matsui, Atsushi Tamura, Mamoru Osawa,...
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