Search results for: Xiaoyun Lu

Items from 1 to 20 out of 72 results

article

Grade classification of human glioma using a convolutional neural network based on mid‐infrared spectroscopy mapping

Wenyu Peng, Shuo Chen, Dongsheng Kong, Xiaojie Zhou, more

Journal of Biophotonics > 15 > 4 > n/a - n/a

This study proposes a convolutional neural network (CNN)‐based computer‐aided diagnosis (CAD) system for the grade classification of human glioma by using mid‐infrared (MIR) spectroscopic mappings. Through data augmentation of pixels recombination, the mappings in the training set increased almost 161 times relative to the original mappings. The pixels of the recombined mappings in the training set...

article

Inside Cover

Wenyu Peng, Shuo Chen, Dongsheng Kong, Xiaojie Zhou, more

Journal of Biophotonics > 15 > 4 > n/a - n/a

This study proposes a convolutional neural network (CNN)‐ based computer‐aided diagnosis (CAD) system for the grade classification of human glioma by using mid‐infrared (MIR) spectroscopic mapping at a single frequency. The proposed system has the advantages of noninvasive, label‐free, time‐saving and highly accurate, which could avoid the limitations of traditional histological diagnosis and will...

article

Teaching now, facing the future

Xiaoyun Lu, Yan Ding

Biochemistry and Molecular Biology Education > 48 > 6 > 568 - 571

To obtain knowledge is not the purpose of education, but to develop one's potential ability and to obtain wisdom is. We are living in a fast changing world and knowledge is growing explosively. Therefore, what facts or information students have known in your class is not the most important thing. What really matters is how efficiently students could learn and how those knowledge they have learned...

article

New Promise and Opportunities for Allosteric Kinase Inhibitors

Xiaoyun Lu, Jeff B. Smaill, Ke Ding

Angewandte Chemie International Edition > 59 > 33 > 13764 - 13776

Drugs that function through allosteric inhibition of kinase signaling represent a promising approach for the targeted discovery of therapeutics. The majority of developed allosteric kinase inhibitors are characterized as type III and IV inhibitors that show good kinome selectivity but generally lack the subtype selectivity of same kinase family. Recently allosteric inhibitors have been developed that...

article

Allosterische Kinaseinhibitoren – Erwartungen und Chancen

Xiaoyun Lu, Jeff B. Smaill, Ke Ding

Angewandte Chemie > 132 > 33 > 13868 - 13881

Wirkstoffe, die das Kinasesignal allosterisch hemmen, sind vielversprechend für die Suche nach hochselektiven Therapeutika. Die meisten allosterischen Kinasehemmer sind Typ‐III‐ oder Typ‐IV‐Inhibitoren, die gute Kinom‐Selektivität aufweisen, aber meist unselektiv für Subtypen innerhalb derselben Kinasefamilie sind. Kürzlich wurden allosterische Hemmstoffe entwickelt, die außerhalb der katalytischen...

article

A Note on Min–Max Pair in Tournaments

Xiaoyun Lu

Graphs and Combinatorics > 2019 > 35 > 5 > 1139-1145

We prove the following results in this paper. Let T be a tournament of order $$n\ge 3$$ n ≥ 3 with vertex set V and arc set E, x a vertex of maximum out-degree and y a vertex of minimum out-degree of T. If $$yx\in E$$ y x ∈ E then there exists a path of length i from x to y for any i with $$2\le i \le n-1$$ 2 ≤ i ≤ n - 1 ; and if $$xy\in E$$ x y ∈ E , then there exists...

article

The Beta-Hydroxybutyrate Suppresses the Migration of Glioma Cells by Inhibition of NLRP3 Inflammasome

Sen Shang, Leilei Wang, Yali Zhang, Haixia Lu, more

Cellular and Molecular Neurobiology > 2018 > 38 > 8 > 1479-1489

Activation of inflammasome leads to the formation of an inflammatory microenvironment which plays an important role in the process of cancer development. Beta-hydroxybutyrate (BHB) is a ketone body that has recently been reported to exert anti-inflammatory effects via inhibition of NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome. Here, we investigated the potential influence of BHB...

article

Beta-hydroxybutyrate Promotes the Expression of BDNF in Hippocampal Neurons under Adequate Glucose Supply

Erling Hu, Huan Du, Xinliang Zhu, Leilei Wang, more

Neuroscience > 2018 > 386 > C > 315-325

Neurobiological evidence suggests that the ketone metabolite β-hydroxybutyrate (BHBA) exerts many neuroprotective functions for the brain. The previous study revealed that BHBA could promote the expression of brain-derived neurotrophic factor (BDNF) at glucose inadequate condition. Here we demonstrated that BHBA administration induced the expression of BDNF in the hippocampus of mice fed with normal...

article

Targeting EGFR^L858R/T790M and EGFR^{L858R/T790M/C797S} resistance mutations in NSCLC: Current developments in medicinal chemistry

Xiaoyun Lu, Lei Yu, Zhang Zhang, Xiaomei Ren, more

Medicinal Research Reviews > 38 > 5 > 1550 - 1581

Both the first‐generation reversible epidermal growth factor receptor (EGFR) inhibitors gefitinib and erlotinib and the second‐generation covalent epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) afatinib have significantly improved the survival of non‐small‐cell lung cancer (NSCLC) patients with activating EGFR mutations. However, a secondary EGFR^T790M mutation leads to the clinically...

article

On Min–Max Pair in Tournaments

Xiaoyun Lu

Graphs and Combinatorics > 2018 > 34 > 4 > 613-618

Let T be a tournament of order $$n\ge 3$$ n≥3 . A pair of distinct vertices x, y of T is called a min–max pair if one of x and y is of minimum out-degree, while the other is of maximum out-degree. Let xy be an arc such that x, y is a min–max pair. We call xy a min–max arc if x has minimum out-degree, and max–min arc otherwise. We prove that if yx is a min–max arc, then there exists a hamiltonian path...

article

Development and optimization of a tumor targeting system based on microbial synthesized PHA biopolymers and PhaP mediated functional modification

Fan Fan, Leilei Wang, Zhenlin Ouyang, Yurong Wen, more

Applied Microbiology and Biotechnology > 2018 > 102 > 7 > 3229-3241

Polyhydroxyalkanoate (PHA) is a class of microbial synthesized biodegradable and biocompatible aliphatic polymer which has been developed into nanoparticles (NPs) for sustained release of hydrophobic compounds. Taking advantage of the natural PHA binding protein PhaP which could be steadily adsorbed onto PHA NPs through hydrophobic interaction, a tumor targeting system was developed in this study...

article

2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors

Xueqiang Li, Christopher P. Guise, Rana Taghipouran, Yuliana Yosaatmadja, more

European Journal of Medicinal Chemistry > 2017 > 135 > C > 531-543

A series of 2-oxo-3, 4-dihydropyrimido[4,5-d]-pyrimidinyl derivatives were designed and synthesized as new irreversible inhibitors of the FGFR family. One of the most promising compounds 2l potently inhibited FGFR1/2/3 with IC₅₀ values of 1.06, 0.84 and 5.38 nM, respectively, whereas its potency against FGFR4 was diminished by an order of magnitude. Compound 2l strongly suppresses the proliferation...

article

Construction of energy-conserving sucrose utilization pathways for improving poly-γ-glutamic acid production in Bacillus amyloliquefaciens

Jun Feng, Yanyan Gu, Yufen Quan, Weixia Gao, more

Microbial Cell Factories > 2017 > 16 > 1 > 1-13

Background Sucrose is an naturally abundant and easily fermentable feedstock for various biochemical production processes. By now, several sucrose utilization pathways have been identified and characterized. Among them, the pathway consists of sucrose permease and sucrose phosphorylase is an energy-conserving sucrose utilization pathway because it consumes less ATP when comparing to other known pathways...

article

Investigating the effects of norepinephrine α1 receptor blockade on dopamine levels: A pilot PET study with [¹¹C]‐(+)‐PHNO in controls

Bernard Le Foll, Thulasi Thiruchselvam, Shawna Xiaoyun Lu, Shakira Mohammed, more

Synapse > 71 > 7 > n/a - n/a

Interest in a role for norepinephrine (NE) in substance use disorders has increased over recent years. In particular, its interaction with dopamine (DA) is of importance. In this study, positron emission tomography (PET) was used to explore the impact of prazosin (an alpha 1 NE antagonist) on DA levels. Healthy volunteers were administered prazosin for approximately 4 weeks at the daily dose of 15...

article

Enhancing poly-γ-glutamic acid production in Bacillus amyloliquefaciens by introducing the glutamate synthesis features from Corynebacterium glutamicum

Jun Feng, Yufen Quan, Yanyan Gu, Fenghong Liu, more

Microbial Cell Factories > 2017 > 16 > 1 > 1-12

Background Poly-γ-glutamic acid (γ-PGA) is a valuable polymer with glutamate as its sole precursor. Enhancement of the intracellular glutamate synthesis is a very important strategy for the improvement of γ-PGA production, especially for those glutamate-independent γ-PGA producing strains. Corynebacterium glutamicum has long been used for industrial glutamate production and it exhibits some unique...

article

A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties

Lei Yu, Minhao Huang, Tianfeng Xu, Linjiang Tong, more

European Journal of Medicinal Chemistry > 2017 > 126 > C > 1107-1117

Structural optimization of pyrido[2,3-d]pyrimidin-7-ones was conducted to yield a series of new selective EGFR^T790M inhibitors with improved pharmacokinetic properties. One of the most promising compound 9s potently suppressed EGFR^L858R/T790M kinase and inhibited the proliferation of H1975 cells with IC₅₀ values of 2.0 nM and 40 nM, respectively. The compound dose-dependently induced reduction of...

article

Immobilization of alkaline polygalacturonate lyase from Bacillus subtilis on the surface of bacterial polyhydroxyalkanoate nano-granules

GanQiao Ran, Dan Tan, WeiEr Dai, XinLiang Zhu, more

Applied Microbiology and Biotechnology > 2017 > 101 > 8 > 3247-3258

Alkaline polygalacturonate lyase (PGL), one of the pectinolytic enzymes, has been widely used for the bioscouring of cotton fibers, biodegumming, and biopulp production. In our study, PGL from Bacillus subtilis was successfully immobilized on the surface of polyhydroxyalkanoate (PHA) nanogranules by fusing PGL to the N-terminal of PHA synthase from Ralstonia eutropha via a designed linker. The PGL-decorated...

article

Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity

Xiaoyun Lu, Jian Tang, Shengyang Cui, Baojie Wan, more

European Journal of Medicinal Chemistry > 2017 > 125 > C > 41-48

A series of pyrazolo[1,5-a]pyridine-3-carboxamide hybrids were designed and evaluated as novel anti-tubercular agents. The representative hybrid 7 exhibited promising in vitro activity against susceptive strain H37Rv and a panel of drug-resistant Mtb strains with MIC values of 0.006 μg/mL and ranged from 0.003 to 0.014 μg/mL, respectively. More importantly, the hybrid 7 also showed very low cytotoxicity,...

article

The rs767649 polymorphism in the promoter of miR-155 contributes to the decreased risk for cervical cancer in a Chinese population

Shizhi Wang, Xiaoli Cao, Bo Ding, Jinfeng Chen, more

Gene > 2016 > 595 > 1 > 109-114

Genetic variants in miRNAs have attracted more and more attention these years because they are capable of altering miRNA function and/or expression, consequently affecting downstream biological pathways and disease risk. The rs767649 polymorphism, locating in the promoter of miR-155, was recently reported to be able to alter transcriptional activity of miR-155 and relate to lung cancer risk. In this...

article

Discovery of new chemical entities as potential leads against Mycobacterium tuberculosis

Xiaoyun Lu, Jian Tang, Zhiyong Liu, Minke Li, more

Bioorganic & Medicinal Chemistry Letters > 2016 > 26 > 24 > 5916-5919

A series of biheterocyclic (1H-indole, benzofuran, pyrazolo[1,5-a]pyrimidine, pyrazolo[1,5-a]pyrimidin-5(4H)-one, imidazo[2,1-b]thiazole and pyrazolo[5,1-b]thiazole) derivatives were synthesized and evaluated for their anti-tubercular activities. The imidazo[2,1-b]thiazoles 9a–c and pyrazolo[5,1-b]thiazoles 10a–c exhibited promising anti-tubercular activity in varying degrees. Especially, the 2,6-dimethylpyrazolo[5,1-b]thiazole...

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INFONA - science communication portal

Search results for: Xiaoyun Lu

Grade classification of human glioma using a convolutional neural network based on mid‐infrared spectroscopy mapping

Inside Cover

Teaching now, facing the future

New Promise and Opportunities for Allosteric Kinase Inhibitors

Allosterische Kinaseinhibitoren – Erwartungen und Chancen

A Note on Min–Max Pair in Tournaments

The Beta-Hydroxybutyrate Suppresses the Migration of Glioma Cells by Inhibition of NLRP3 Inflammasome

Beta-hydroxybutyrate Promotes the Expression of BDNF in Hippocampal Neurons under Adequate Glucose Supply

Targeting EGFR^L858R/T790M and EGFR^{L858R/T790M/C797S} resistance mutations in NSCLC: Current developments in medicinal chemistry

On Min–Max Pair in Tournaments

Development and optimization of a tumor targeting system based on microbial synthesized PHA biopolymers and PhaP mediated functional modification

2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors

Construction of energy-conserving sucrose utilization pathways for improving poly-γ-glutamic acid production in Bacillus amyloliquefaciens

Investigating the effects of norepinephrine α1 receptor blockade on dopamine levels: A pilot PET study with [¹¹C]‐(+)‐PHNO in controls

Enhancing poly-γ-glutamic acid production in Bacillus amyloliquefaciens by introducing the glutamate synthesis features from Corynebacterium glutamicum

A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties

Immobilization of alkaline polygalacturonate lyase from Bacillus subtilis on the surface of bacterial polyhydroxyalkanoate nano-granules

Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity

The rs767649 polymorphism in the promoter of miR-155 contributes to the decreased risk for cervical cancer in a Chinese population

Discovery of new chemical entities as potential leads against Mycobacterium tuberculosis

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