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Phosphatidic acid (PA) was observed to stimulate protein synthesis in adult cardiomyocytes in a time- and concentration-dependent manner. The maximal stimulation in protein synthesis (142 ± 12% vs 100% as the control) was achieved at 10 μM PA within 60 min and was inhibited by actinomycin D (107 ± 4% of the control) or cycloheximide (105 ± 6% of the control). The increase in protein synthesis due...
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