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BACKGROUND
Allogeneic natural killer (NK) cell adoptive immunotherapy is a growing therapeutic option for patients. Clinical‐scale production of NK cells using immunomagnetic selection complies with current good manufacturing practices (cGMPs) and allows for closed‐system, automated purification. We report our experience with CD3/CD19 cell‐depleted (CD3/CD19dep) NK cell production and compare to...
BACKGROUND: Natural killer (NK) cells have shown promise in the treatment of malignancy. However, the widespread use of these cells may be limited by both the lack of resources and the expertise needed to manufacture them and the apparent need to use only fresh cells. The NHLBI‐sponsored Production Assistance for Cellular Therapies group was established to provide the resources and expertise to carry...
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