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As PET candidate tracers for EGFr-TK, five 4-(anilino)quinazoline derivatives, each fluorinated in the aniline moiety, were prepared. Each was tested in vitro for inhibition of EGFr autophosphorylation in A431 cell line. The leading compounds were then radiolabeled with 18 F and cell binding experiments, biodistribution and PET studies in A431 tumor-bearing mice were performed. Metabolic...
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