Wyniki wyszukiwania dla: Takahiro Kobayashi

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A case of erythema elevatum diutinum with pyoderma gangrenosum

Mizuki Nose, Kyoko Kanno, Mai Komatsu, Takahiro Kobayashi, więcej

Australasian Journal of Dermatology > 64 > 2 > 288 - 291

artykuł

Thioxothiazolidin derivative, 4‐OST, inhibits melanogenesis by enhancing the specific recruitment of tyrosinase‐containing vesicles to lysosome

Kenta Isogawa, Masataka Asano, Masumi Hayazaki, Kenichi Koga, więcej

Journal of Cellular Biochemistry > 122 > 6 > 667 - 678

Tyrosinase catalyzes the rate‐limiting step in melanin synthesis. Melanin is synthesized from l‐tyrosin in the melanosomes, where tyrosinase and other melanogenic factors are recruited via the vesicle transport system. Genetic and biochemical approaches have revealed a correlation between impairments in the vesicle transport system and albinism. However, the specificity of the individual transport...

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Correction to: Particle toxicology and health - where are we?

Michael Riediker, Daniele Zink, Wolfgang Kreyling, Günter Oberdörster, więcej

Particle and Fibre Toxicology > 2019 > 16 > 1 > 1-1

After the publication of this article [1] it was hihglighted that the number of deaths related to natural disasters was incorrectly reported in the second paragraph of section Hazards from Natural particulates and the evolution of the biosphere. This correction article shows the correct and incorrect statement. This correction does not change the idea presented in the article that from an evolutionary...

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Influence of ABCB1 polymorphisms on the pharmacokinetics and toxicity of lenalidomide in patients with multiple myeloma

Takahiro Kobayashi, Masatomo Miura, Maiko Abumiya, Yumiko Akamine, więcej

Medical Oncology > 2019 > 36 > 6 > 1-7

Individual diversity in plasma concentrations of lenalidomide occurs despite dosage modifications based on creatinine clearance (CCr), which can lead to unexpected toxicity. We have previously identified a cutoff value of area under the concentration–time curve (AUC_0–24) for lenalidomide to avoid severe toxicity. Here, we investigated the association between ABCB1 polymorphisms and pharmacokinetics...

artykuł

Particle toxicology and health - where are we?

Michael Riediker, Daniele Zink, Wolfgang Kreyling, Günter Oberdörster, więcej

Particle and Fibre Toxicology > 2019 > 16 > 1 > 1-33

Background Particles and fibres affect human health as a function of their properties such as chemical composition, size and shape but also depending on complex interactions in an organism that occur at various levels between particle uptake and target organ responses.While particulate pollution is one of the leading contributors to the global burden of disease, particles are also increasingly used...

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Relationship between clinical course of nivolumab-related myositis and immune status in a patient with Hodgkin’s lymphoma after allogeneic hematopoietic stem cell transplantation

Takahiro Kobayashi, Yong-mei Guo, Takaya Yamashita, Miho Nara, więcej

International Journal of Hematology > 2019 > 109 > 3 > 356-360

Although programmed cell death (PD)-1 blockade induces immune-related adverse events (irAEs), little is known about the safety of PD-1 blockade after allogeneic hematopoietic stem cell transplantation (HSCT). Here, we describe immune system changes during nivolumab-related myositis in a patient with Hodgkin’s lymphoma after allogeneic HSCT; to our knowledge, this is the first such report in the literature...

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Unsuppressed serum albumin levels may jeopardize the clinical relevance of the international staging system to patients with light chain myeloma

Tetsuhiro Kasamatsu, Shuji Ozaki, Takayuki Saitoh, Jun Konishi, więcej

Hematological Oncology > 36 > 5 > 792 - 800

The international staging system (ISS) is the most commonly used risk‐stratification system for patients with multiple myeloma (MM) and is determined by serum albumin and β2‐microglobulin levels. In the two determinants, β2‐microglobulin levels are frequently observed to be elevated in patients with myeloma, particularly in those with renal impairment. In comparison with patients with intact immunoglobulin...

artykuł

Serum and histological IgG4-negative type 1 autoimmune pancreatitis

Yuichi Takano, Takahiro Kobayashi, Fumitaka Niiya, Eiichi Yamamura, więcej

Clinical Journal of Gastroenterology > 2019 > 12 > 3 > 232-238

A 66-year-old man who was on oral medication for type 2 diabetes experienced a rapid decline in glycemic control (increase in glycosylated hemoglobin level from 7.7 to 10.2% over 3 months). Abdominal ultrasonography revealed a 20-mm hypoechoic mass in the pancreatic tail. Serum tumor marker carbohydrate antigen 19–9 and DUPAN2 levels were within the respective normal ranges; serum IgG4 level was also...

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Anorexia nervosa-associated pancytopenia mimicking idiopathic aplastic anemia: a case report

Masahiro Takeshima, Hiroyasu Ishikawa, Akihiro Kitadate, Ryo Sasaki, więcej

BMC Psychiatry > 2018 > 18 > 1 > 1-5

Background Patients with anorexia nervosa (AN) often present with pancytopenia. In most cases described in the literature, AN with pancytopenia demonstrates gelatinous marrow transformation (GMT), which is a typical bone marrow feature of malnutrition. Differentiation of AN-associated pancytopenia from other types of pancytopenia, especially idiopathic aplastic anemia (IAA), has not been studied....

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The potential role of clarithromycin addition to lenalidomide and dexamethasone therapy (BiRd) in multiple myeloma

Takahiro Kobayashi, Masatomo Miura, Maiko Abumiya, Takenori Niioka, więcej

Annals of Hematology > 2018 > 97 > 6 > 1097-1099

artykuł

Development of high resolution phoswich depth-of-interaction block detectors utilizing Mg co-doped new scintillators

Takahiro Kobayashi, Seiichi Yamamoto, Jung-Yeol Yeom, Kei Kamada, więcej

Nuclear Instruments and Methods in Physics Research Section A: Accelerators,... > 2017 > 875 > C > 111-118

To correct for parallax error in positron emission tomography (PET), phoswich depth-of-interaction (DOI) detector using multiple scintillators with different decay times is a practical approach. However not many scintillator combinations suitable for phoswich DOI detector have been reported. Ce doped Gd₃Ga₃Al₂O₁₂ (GFAG) is a newly developed promising scintillator for PET detector, which has high density,...

artykuł

Extramedullary plasmacytoma of the ureter in an HIV-positive patient

Takashi Nagai, Takehiko Okamura, Yosuke Taki, Yutaro Tanaka, więcej

International Cancer Conference Journal > 2017 > 6 > 4 > 171-174

A 45-year-old Japanese man, who was undergoing HIV infection treatment, was aware that he had gross hematuria, and he was diagnosed as having a ureteral tumor by radiographic examination. Therefore, he was referred to our department for further examination and treatment. We considered that the ureteral tumor was a urothelial carcinoma (cT2N0M0) because of the left ureteral tumor and urine cytology...

artykuł

Clinical impact of complete revascularization in elderly patients with multi-vessel coronary artery disease undergoing percutaneous coronary intervention: A sub-analysis of the SHINANO registry

Mikiko Harada, Takashi Miura, Takahiro Kobayashi, Hideki Kobayashi, więcej

International Journal of Cardiology > 2017 > 230 > C > 413-419

Prior reports have revealed that complete revascularization (CR) by percutaneous coronary intervention (PCI) decreased ischemic events. However, little is known about the efficacy of CR using PCI in elderly patients with multi-vessel coronary artery disease (CAD). We evaluated the 1-year effectiveness of CR-PCI in elderly patients (≥75years old) with multi-vessel CAD.The SHINANO Registry, a prospective,...

artykuł

Basic performance of Mg co-doped new scintillator used for TOF-DOI-PET systems

Takahiro Kobayashi, Seiichi Yamamoto, Satoshi Okumura, Jung Yeol Yeom, więcej

Nuclear Instruments and Methods in Physics Research Section A: Accelerators,... > 2017 > 842 > C > 14-19

Phoswich depth-of-interaction (DOI) detectors utilizing multiple scintillators with different decay time are a useful device for developing a high spatial resolution, high sensitivity PET scanner. However, in order to apply pulse shape discrimination (PSD), there are not many combinations of scintillators for which phoswich technique can be implemented. Ce doped Gd₃Ga₃Al₂O₁₂ (GFAG) is a recently developed...

artykuł

Therapeutic drug monitoring enables safe and effective lenalidomide therapy in patients with multiple myeloma on hemodialysis

Takahiro Kobayashi, Takenori Niioka, Masatomo Miura, Naoto Takahashi

Annals of Hematology > 2016 > 95 > 12 > 2087-2088

artykuł

Timing performance measurements of Si-PM-based LGSO phoswich detectors

Seiichi Yamamoto, Takahiro Kobayashi, Satoshi Okumura, Jung Yeol Yeom

Nuclear Instruments and Methods in Physics Research Section A: Accelerators,... > 2016 > 821 > C > 101-108

Since the timing resolution was significantly improved using silicon photomultipliers (Si-PMs) combined with fast scintillators, we expect that phoswich detectors will be used in future TOF-PET systems. However, no practical phoswich detector has been proposed for TOF-PET detectors. We conducted timing performance measurements of phoswich detectors comprised of two types of Ce-doped LGSO scintillators...

artykuł

PD31-01 ADMINISTRATION OF THE SELECTIVE ALPHA 1A ADRENOCEPTOR ANTAGONIST SILODOSIN FACILITATES EXPULSION OF SIZE 5 - 10 MM DISTAL URETERAL STONES, AS COMPARED TO CONTROL.

Yasunori Itoh, Atsushi Okada, Kazumi Taguchi, Yasuhiko Hirose, więcej

The Journal of Urology > 2016 > 195 > 4(S) > e717

artykuł

MP58-13 THE MECHANISM OF RENAL STONE FORMATION AND RENAL FAILURE INDUCED BY MELAMINE AND CYANURIC ACID; LONG-TERM EXPERIMENT RESULTS

Takahiro Kobayashi, Atsushi Okada, Ryossuke Ando, Keiichi Tozawa, więcej

The Journal of Urology > 2016 > 195 > 4(S) > e781

artykuł

Exposure assessment and heart rate variability monitoring in workers handling titanium dioxide particles: a pilot study

Sahoko Ichihara, Weihua Li, Seiichi Omura, Yuji Fujitani, więcej

Journal of Nanoparticle Research > 2016 > 18 > 3 > 1-14

Titanium dioxide (TiO₂) particles are used for surface coating and in a variety of products such as inks, fibers, food, and cosmetics. The present study investigated possible respiratory and cardiovascular effects of TiO₂ particles in workers exposed to this particle at high concentration in a factory in China. The diameter of particles collected on filters was measured by scanning electron microscopy...

artykuł

Restricted infection of murine cytomegalovirus (MCMV) in neonatal mice with MCMV-induced sensorineural hearing loss

Kazufumi Ikuta, Hiroshi Ogawa, Hiromi Hashimoto, Wataru Okano, więcej

Journal of Clinical Virology > 2015 > 69 > Complete > 138-145

Congenital infection with human Cytomegalovirus (HCMV) is known to be a causative agent of sensorineural hearing loss (SNHL).To clarify the nongenetic etiology of SNHL by identifying the Cytomegalovirus (CMV)-infected region in the cochleae.We established an animal model of SNHL by injecting neonatal Balb/c mice with intracerebral murine Cytomegalovirus (MCMV) within 24h after delivery.At 3 weeks...

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