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We have found that the growth of human pancreatic cancer cells MIAPaCa-2, induced by human pancreatic phospholipase A 2 group I (hPLA 2 -I), is mediated via its specific receptor but not via its catalytic property. The present study showed that the activation of mitogen-activated protein kinase (MAPK) cascade in MIAPaCa-2 cells is induced by hPLA 2 -I: this digestive enzyme...
Phospholipase A 2 (PLA 2 ) from human pancreas, designated hPLA 2 -I, functions as a digestive enzyme. Interestingly, the present study demonstrated that the mature form of hPLA 2 -I stimulated the growth of a human pancreatic cancer cell line MIAPaCa-2, whereas the pro-form was ineffective. PLA 2 s from Laticauda semifasciata fraction I, Crotalus adamanteus...
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