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Affinity‐based probes (AfBPs) provide a powerful tool for large‐scale chemoproteomic studies of drug–target interactions. The development of high‐quality probes capable of recapitulating genuine drug–target engagement, however, could be challenging. “Minimalist” photo‐crosslinkers, which contain an alkyl diazirine group and a chemically tractable tag, could alleviate such challenges, but few are currently...
Schnell und effizient: Eine Bibliothek trans‐Cycloocten(TCO)‐modifizierter kleiner Moleküle wurde mit der schnellsten bekannten bioorthogonalen Reaktion auf Tetrazin‐funktionalisierten Glasträgern immobilisiert. Der erhaltene Mikroarray wurde gegen eine Vielzahl humaner Bromodomänen getestet, um Inhibitoren von Protein‐Protein‐Wechselwirkungen zu identifizieren.
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