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Selenocysteine Se-conjugates (e.g. methylselenocysteine) have been shown to be potent chemopreventive and chemoprotective agents, and inducers of apoptosis. Although the mechanism of action remains to be elucidated, β-elimination of these compounds by β-lyase enzymes into corresponding selenols, pyruvate and ammonia is thought to be critical. This study describes in vitro β-lyase activity in nine...
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