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Human D-type prostanoid (DP) and E-type prostanoid 2 (EP2) receptors are regarded as the most closely related receptors among prostanoid receptors. Although these receptors are generated by tandem duplication, their physiological outputs often oppose one another. In the present study, we extracted mutations occurring in the coding regions of both receptors using the 1000 genome project database and...
Invertebrate troponin C typically contains Ca 2+ -specific binding sites, sites II and IV, in the N- and C-terminal domains, respectively. To investigate the roles of these sites for Ca 2+ -dependent regulation of muscle contraction, we generated lobster troponin C mutants, and analyzed their Ca 2+ -binding properties and regulatory effects on actomyosin–tropomyosin Mg-ATPase...
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