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Apurinic/apyrimidinic (AP) endonucleases are versatile DNA repair enzymes that possess a variety of nucleolytic activities, including endonuclease activity at AP sites, 3′ phosphodiesterase activity that can remove a variety of ligation-blocking lesions from the 3′ end of DNA, endonuclease activity on oxidative DNA lesions, and 3′ to 5′ exonuclease activity. There are two families of AP endonucleases,...
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