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Objective
In many rheumatoid arthritis (RA) patients, disease is controlled with anti–tumor necrosis factor (anti‐TNF) biologic therapies. However, in a significant number of patients, the disease fails to respond to anti‐TNF therapy. We undertook the present study to examine the hypothesis that rare and low‐frequency genetic variants might influence response to anti‐TNF treatment.
Methods
We sequenced...
ObjectiveA recent high‐density fine‐mapping (ImmunoChip) study of genetic associations in rheumatoid arthritis (RA) identified 14 risk loci with validated genome‐wide significance, as well as a number of loci showing associations suggestive of significance (P = 5 × 10−5 < 5 × 10−8), but these have yet to be replicated. The aim of this study was to determine whether these potentially significant...
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