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The functional activity of a series of 5-HT 1A receptor ligands has been evaluated in a cell line expressing the human 5-HT 1A receptor (h5-HT 1A . CHO) using the agonist-stimulated increase in extracellular acidification rate, measured with the microphysiometer, as a functional assay. Both 5-CT and 8-OH-DPAT were potent agonists in stimulating an increase in...
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