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Among the bisphosphonates (BPs), the aminobisphosphonates (aminoBPs) have much stronger bone-resorption–inhibitory activities (BRIAs) than nonaminobisphosphonates (nonaminoBPs). However, aminoBPs have inflammatory effects. We previously reported that in mice: (i) all aminoBPs tested (10–40 μmol/kg) induced various inflammatory reactions (including induction of histidine decarboxylase), whereas clodronate...
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