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Having found previously that leukemic cells with multidrug resistant (MDR) phenotype, but not their sensitive counterparts, exhibit collateral sensitivity to cold stress in a P-gp-dependent manner, our aim was to study the signaling pathways involved in this phenomenon in sensitive (L1210) and resistant cells (L1210R and CBMC-6). It was observed that the acquisition of MDR phenotype by leukemic cells...
The acquisition of a multidrug‐resistant (MDR) phenotype by tumor cells that renders them unsusceptible to anti‐neoplasic agents is one of the main causes of chemotherapy failure in human malignancies. The increased expression of P‐glycoprotein (MDR1, P‐gp, ABCB1) in tumor cells contributes to drug resistance by extruding chemotherapeutic agents or by regulating programmed cell death. In a study of...
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