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Technology for reconstituting an entire organ from single cells is expected to be applied for replacement of organs lost or damaged due to disease, injury, or aging in regenerative therapy. In this study, we demonstrated that a bioengineered primordial organ from epithelial and mesenchymal cells of murine tooth germ successfully achieved eruption and developed into a tooth with proper functions in...
The regenerative therapy ultimately aims to develop bioengineered organs that can replace lost or damaged organs following disease, injury or aging. Recently, we showed that the artificial organ germ, which generates a structurally correct tooth, could be reconstituted by in vitro cell manipulation (Nature Methods 4, 227-230, 2007). In this study, we revealed that neural crest-like cells, which were...
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