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Antibodies are widely considered to be a frequent primary and often mechanistic correlate of protection of approved vaccines; thus evaluating the antibody response is of critical importance in attempting to understand and predict the efficacy of novel vaccine candidates. Historically, antibody responses have been analyzed by determining the titer of the humoral response using measurements such as...
A global human immunodeficiency virus‐1 (HIV‐1) vaccine will have to elicit immune responses capable of providing protection against a tremendous diversity of HIV‐1 variants. In this review, we first describe the current state of the HIV‐1 vaccine field, outlining the immune responses that are desired in a global HIV‐1 vaccine. In particular, we emphasize the likely importance of Env‐specific neutralizing...
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