The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Cidofovir (CDV) was used for in vitro selection of a human herpesvirus 6 (HHV-6) mutant with decreased susceptibility to this drug. The resulting mutant was highly resistant to CDV as compared to its sensitive counterpart (inhibitory concentration 50% (IC 50 ): 213μM versus 1.8μM). Its replication fitness was not impaired. Genotypic characterization of the resistant virus revealed a mutation...
Human herpesvirus 6 (HHV-6) is latent in the majority of the adult population. Due to its ability of causing opportunistic infections, alone or in concert with the other β-herpesviruses human cytomegalovirus (HCMV) and HHV-7, its importance as a pathogen in immunocompromised patients has increasingly been recognized. We here report the characterization of the main antiviral target, the HHV-6 DNA polymerase,...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.