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The present study examined the effects of dronabinol, a United States FDA‐approved synthetic cannabinoid receptor agonist, on morphine (a prototypic μ‐opioid receptor agonist)‐induced dopamine‐related behaviors in animals. Dronabinol suppressed the rewarding effects of morphine in rats and its emetic effects in ferrets. Furthermore, the morphine‐induced increase in dopamine release from the nucleus...
The management of excessive adverse effects of opioids is a major clinical problem. The present study was undertaken to investigate the effect of a selective γ-aminobutyric acid (GABA) B receptor agonist baclofen on the μ-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects. Either morphine or fentanyl produced a dose-dependent antinociceptive effect in both ferrets...
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