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Previous studies have shown that sigma‐1 receptor chaperone (Sig‐1R) ligands can regulate pain‐related behaviors, and Sig‐1R itself can regulate μ‐opioid receptor functions as well as signal transduction. Even though (±)‐pentazocine has been used clinically for the treatment of pain through opioid receptors, (+)‐pentazocine is known to be a selective Sig‐1R agonist. To the best of our knowledge, there...
Background and PurposeOxycodone and morphine are μ‐opioid receptor agonists prescribed to control moderate‐to‐severe pain. Previous studies suggested that these opioids exhibit different analgesic profiles. We hypothesized that distinct mechanisms mediate the differential effects of these two opioids and investigated the role of G protein‐gated inwardly rectifying potassium (KIR3 also known as GIRK)...
In the present study, we investigated the possible development of tolerance to the antihyperalgesic effect of µ‐opioid receptor (MOR) agonists under a neuropathic pain‐like state. Repeated treatment with fentanyl, but not morphine or oxycodone, produced a rapid development of tolerance to its antihyperalgesic effect in mice with sciatic nerve ligation. Like the behavioral study, G‐protein activation...
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