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Sphingosine 1‐phosphate (S1P) exerts its various physiological and pathological effects by interacting with G protein‐coupled receptors. In addition, S1P can induce biological dysfunction in fibroblast‐like synoviocytes (FLSs) in the development of rheumatoid arthritis (RA). However, the mechanism underlying this S1P‐induced dysfunction remains unclear. An imbalance between Gαi and Gαs can affect...